Ozempic Side Effects

Common side effects

The most frequently reported side effects are gastrointestinal: nausea, diarrhea, vomiting, and constipation. These are typically mild to moderate and tend to decrease over the first 8–12 weeks as the dose is gradually titrated upward.

Less common side effects

• Headache or fatigue, especially early in treatment
• Injection-site reactions
• Changes in appetite beyond the intended effect

Serious but rare risks

Serious but rare side effects include pancreatitis and gallbladder problems. Your prescribing clinician will review your full medical history and risk profile before starting treatment, and should be your first call if you notice severe or persistent symptoms.

Managing side effects

Many patients find that eating smaller meals, avoiding high-fat foods, and staying hydrated helps during the titration period. Don't adjust your dose on your own — any changes should go through your prescribing clinician.